cancer, and the pleasure of the weed

Okay, can someone ELI5 why I’m supposed to pick “the pleasure of the weed” here?

Like, this isn’t some abstract theoretical toy, this Smoking Lesion, or as it would be better called, Exercise Genetics problem is actually a thing in my IRL

It has probabilistic Azathoth instead of absolute Omega, and I may be able to peek into the boxes before selecting thanks to modern technology, but even then it would seem that me being the sort of clockwork thing that has the property “one-boxes” would make me likely to be the sort of a clockwork thing that has the property “gets a million dollars” and being the sort of a clockwork thing that has the property “one-boxes even if the box turns out to be empty when peeking into it” would make it extra-likely?

Thus, I should be the sort of a person who likes exercise so I’d have the genes that make one like exercise and live long, even if I turn out to not have such genes, because the sort of a person who has good genes would make such a choice?

Then again, turning it the other way around into the Psychosis Weed problem (people with early psychosis are more likely to self-medicate) doesn’t make me interested in impacting my choice on whether or not to choose “the pleasure of the weed” to avoid psychosis-related genes retroactively.

One could argue that the question is different because self-medicating is caused by symptoms and thus choosing to have symptoms or not (yeah, good luck with that) would be the thing that matters while the choice to exercise is directly controlled by the exact neurochemistry the Exercise Genes are about, and I think that one is probably “the” reason for it. So using that logic I’d determine my choice in the Smoking Lesion based on the mechanism of action of the lesion.

On the other hand, it could be that I’m supposed to choose not exercising and I just inherently enjoy exercise because I have the good genes that make me live long and prosper and thus my neurochemistry is motivated to interpret the Exercise Genetics that way?

Because it is pleasure. Why would you not pick pleasure.

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